Mozzarella Pesto Chicken Grilled Cheese

Featured in: Oregano-Warm Homestyle Plates

This Mozzarella Pesto Chicken Grilled Cheese combines tender shredded chicken breast with aromatic basil pesto and creamy melted mozzarella, all nestled between toasted sourdough or Italian bread. The sandwich is buttered on the outside and grilled until the bread achieves a beautiful golden-brown crust while the cheese melts into gooey perfection.

Preparation takes just 10 minutes, with another 10 minutes of cooking time. This American-Italian fusion dish serves two and delivers 520 calories per sandwich. Optional additions like fresh tomato slices, Parmesan cheese, and basil leaves elevate the flavors further. Perfect for lunch or a quick dinner, it pairs beautifully with crisp Italian wines or sparkling water.

Updated on Tue, 20 Jan 2026 13:53:00 GMT
A close-up of a golden, buttery Mozzarella Pesto Chicken Grilled Cheese sandwich, cut in half to show layers of melted cheese and shredded chicken. Save
A close-up of a golden, buttery Mozzarella Pesto Chicken Grilled Cheese sandwich, cut in half to show layers of melted cheese and shredded chicken. | velvetoregano.com

The smell of butter hitting a hot skillet still takes me back to my tiny first apartment, where I discovered that grilled cheese could be dinner, not just a side. I'd been experimenting with leftover rotisserie chicken one rainy Tuesday, feeling too tired to cook anything elaborate. The moment I took that first bite—crispy bread giving way to melty mozzarella and bright pesto—I knew I'd stumbled onto something special. Now it's my go-to when I want comfort food that feels a little fancy but takes barely any effort.

Last summer, my sister came over for a quick lunch between meetings. I made these sandwiches, and she literally stopped mid sentence after her first bite, eyes wide. She now claims I ruined regular grilled cheese for her forever because nothing else compares to this version. We ended up sitting at the counter for an hour just talking and eating, totally ignoring her schedule.

Ingredients

  • Sourdough or Italian bread: Choose something sturdy that can hold up to the filling without getting soggy, slightly stale bread actually works brilliantly here
  • Fresh mozzarella: This melts differently than shredded cheese, creating those gorgeous stretchy strings we all love in a grilled cheese
  • Unsalted butter: Softening it first makes spreading so much easier and ensures even coverage for that perfect golden crust
  • Cooked shredded chicken breast: Rotisserie chicken from the grocery store works perfectly, or use leftover chicken from another meal
  • Basil pesto: Homemade is lovely but store bought is absolutely fine, just check that you like the flavor profile first

Instructions

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Spread the pesto base:
Lay out your bread slices and spread about a tablespoon of pesto on two pieces, going almost to the edges but leaving a tiny border so it doesnt drip out
Layer the chicken:
Distribute your shredded chicken evenly over the pesto, pressing it down gently so it stays put when you flip the sandwich later
Add the mozzarella:
Arrange your mozzarella slices over the chicken, and if you're using tomato or fresh basil, layer them on top now
Close the sandwiches:
Top with the remaining bread slices to create two complete sandwiches, pressing down lightly to help everything stick together
Butter the exterior:
Spread softened butter on the outside of both top and bottom slices, covering every bit that will touch the pan
Grill to perfection:
Heat your skillet over medium heat, add the sandwiches, and press gently with your spatula, cooking for about 4 minutes per side until golden brown and the cheese is completely melted
Rest and serve:
Let the sandwiches sit for just one minute after cooking, then cut them in half and serve while they're still hot and gooey
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A freshly made Mozzarella Pesto Chicken Grilled Cheese on a wooden cutting board, featuring toasted sourdough bread and vibrant green pesto spread. Save
A freshly made Mozzarella Pesto Chicken Grilled Cheese on a wooden cutting board, featuring toasted sourdough bread and vibrant green pesto spread. | velvetoregano.com

My husband now requests this every Sunday during football season, and it's become this weird little tradition I didn't expect to start. There's something about the combo of warm, melty cheese and bright, herby pesto that makes everything feel right with the world, even when your team is losing.

Bread Choices That Work

I've tested countless bread options, and while sourdough is my absolute favorite for its tang and crunch, ciabatta creates this incredible bubbly crust that's hard to beat. Multigrain adds lovely texture but can sometimes overwhelm the delicate pesto flavor, so use it sparingly. Whatever you choose, avoid super soft sandwich bread because it'll turn to mush before the cheese melts.

Make It Your Own

Sometimes I add a thin layer of sun dried tomatoes for extra umami, or swap in provolone for a sharper bite. My friend who hates mozzarella uses sharp cheddar and swears it's even better than the original. The recipe is forgiving enough that you can play around based on what you have in your fridge.

Serving Ideas

A simple side salad with lemon vinaigrette cuts through the richness beautifully. Tomato soup is classic for a reason, especially on cold winter nights when you need maximum comfort. These also reheat surprisingly well the next day if you're meal prepping for lunch.

  • Crisp apple slices make a surprisingly perfect pairing on the side
  • A glass of chilled white wine balances the warm, gooey sandwich
  • Leftovers can be wrapped in foil and reheated in a 350°F oven for 10 minutes
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The gooey interior of a Mozzarella Pesto Chicken Grilled Cheese, with melted mozzarella and shredded chicken peeking out from between crispy bread slices. Save
The gooey interior of a Mozzarella Pesto Chicken Grilled Cheese, with melted mozzarella and shredded chicken peeking out from between crispy bread slices. | velvetoregano.com

Hope this becomes your new comfort food staple too, because everyone deserves a sandwich that makes them pause and appreciate the simple joy of good food.

Recipe FAQ

Can I use store-bought rotisserie chicken?

Yes, absolutely. Rotisserie chicken is an excellent convenience option and works perfectly in this sandwich. Simply shred the meat and proceed with the rest of the instructions.

What type of bread works best?

Sourdough and Italian bread are ideal, but ciabatta and multigrain varieties offer interesting texture alternatives. Choose bread thick enough to hold the filling without falling apart during grilling.

How do I make the cheese melt evenly?

Cook over medium heat rather than high heat, and press the sandwich gently with a spatula while grilling. This ensures even contact with the pan and allows the mozzarella to melt completely before the bread over-browns.

Is there a vegetarian version available?

Yes. Replace the chicken with grilled vegetables like zucchini, roasted peppers, or eggplant. The pesto and mozzarella provide plenty of flavor and richness to make the sandwich satisfying.

What allergens should I be aware of?

This sandwich contains dairy (mozzarella, butter, Parmesan) and wheat/gluten from bread. Store-bought pesto may contain tree nuts like pine nuts, so check labels if serving guests with nut allergies.

Can I make homemade pesto instead of store-bought?

Definitely. Homemade pesto using fresh basil, garlic, pine nuts, Parmesan, and olive oil provides superior flavor. Use the same amount (3 tablespoons) as you would store-bought pesto.

Mozzarella Pesto Chicken Grilled Cheese

Shredded chicken, basil pesto, and melted mozzarella grilled between buttered bread for a delicious, quick meal.

Time to Prep
10 minutes
Time to Cook
10 minutes
Overall Time
20 minutes
Written by Adrian Sanders


Skill Level Easy

Cuisine American/Italian Fusion

Portions 2 Serving Size

Diet Preferences None specified

What You'll Need

Bread & Dairy

01 4 slices sourdough or Italian bread
02 4 oz fresh mozzarella, sliced or shredded
03 2 tbsp unsalted butter, softened

Protein

01 1 cup cooked, shredded chicken breast

Sauces & Spreads

01 3 tbsp basil pesto

Optional Add-Ins

01 2 tbsp grated Parmesan cheese
02 1 small tomato, thinly sliced
03 Fresh basil leaves

How To Make It

Step 01

Prepare bread base: Lay out bread slices and spread 1 to 1.5 tbsp pesto onto two slices evenly.

Step 02

Layer chicken: Distribute shredded chicken breast evenly over pesto-covered slices.

Step 03

Add cheese and toppings: Layer mozzarella cheese over chicken. Top with tomato slices and fresh basil if desired. Sprinkle with Parmesan cheese for additional flavor.

Step 04

Assemble sandwiches: Place remaining bread slices on top to form complete sandwiches.

Step 05

Butter exterior: Spread softened butter on the outside surfaces of each sandwich on both top and bottom sides.

Step 06

Cook sandwiches: Heat a large skillet or grill pan over medium heat. Place sandwiches in pan and press lightly with spatula. Cook for 3 to 4 minutes per side until bread is golden brown and cheese is melted.

Step 07

Finish and serve: Remove from skillet and let rest for 1 minute. Cut in half and serve warm.

Needed Tools

  • Skillet or grill pan
  • Spatula
  • Knife
  • Cutting board

Allergy Notice

Review every ingredient for allergies and reach out to a health expert if you have questions.
  • Contains dairy: mozzarella, butter, Parmesan cheese
  • Contains wheat and gluten from bread
  • May contain tree nuts if pesto contains pine nuts
  • Check store-bought pesto labels for nut and cheese allergens

Nutrition Details (per portion)

For informational use only—not to replace doctor’s advice.
  • Caloric Value: 520
  • Total Fat: 27 g
  • Carbohydrates: 32 g
  • Proteins: 36 g